IVF versus ICSI in patients without severe male factor infertility: a randomized clinical trial
DOI:10.1038/s41591-025-03621-x by nature medicine in 2025
[2669]
Compared with conventional insemination, intracytoplasmic sperm injection provides no benefit in cases of nonmale factor infertility as evidenced by comparable euploidy rate
DOI:10.1016/j.fertnstert.2023.04.020 by Fertility and Sterility in 2024
[2382]
Key Points
see Q&A
57
This study suggests that IVF may yield better maternal outcomes and more favorable neonatal results than ICSI for older women with nonmale factor infertility.
137
ICSI was not associated with improved clinical or neonatal outcomes in FET cycles with non-male factor infertility.
138
ICSI exhibited no significant effect on neonatal sex ratio in FET cycles with non-male factor infertility.
TextBook
ALWAYS ICSI? A SWOT analysis [Free access via PubMed]
DOI:10.1007/s10815-020-01836-0 by Journal of Assisted Reproduction and Genetics in 2020
[1339]
Modelling and comparing the use of IVF and ICSI in Australia
DOI:10.1007/s10815-024-03163-0 by Journal of Assisted Reproduction and Genetics in 2024
[986]
Comparing reproductive outcomes between conventional in vitro fertilization and nonindicated intracytoplasmic sperm injection in autologous embryo transfer cycles: a Society for Assisted Reproductive Technology Clinic Outcome Reporting System Study
DOI:10.1016/j.xfre.2023.10.004 by F&S Reports, in 2024
[770]
Efficacy of intracytoplasmic sperm injection in women with non-male factor infertility: A systematic review and meta-analysis
DOI:10.1111/aogs.14698 by Acta Obstetricia et Gynecologica Scandinavica in 2023
[597]
Comparing reproductive outcomes between conventional IVF and non-recommended ICSI in autologous embryo transfer cycles: A SART CORS Study
DOI:.1016/j.xfre.2023.10.004 by F&S Reports, in 2023
[555]
Intracytoplasmic sperm injection versus conventional in vitro fertilisation in couples with males presenting with normal total sperm count and motility
DOI:10.1002/14651858.CD001301.pub2 by Cochrane Database Syst Rev. in 2023
[164]
Recent Publications
Insemination methods for embryos transferred in frozen-thawed embryo transfer cycles do not impact reproductive outcomes in couples with non-male factor infertility
DOI:10.1038/s41598-025-97051-x by Scientific Reports in 2025
[2686]
IVF versus ICSI in patients without severe male factor infertility: a randomized clinical trial
DOI:10.1038/s41591-025-03621-x by nature medicine in 2025
[2669]
Pregnancy and neonatal outcomes of intracytoplasmic sperm injection versus in vitro fertilization in fresh cycles of women with advanced maternal age and nonmale factor infertility: A cross-sectional study
DOI:10.18502/ijrm.v23i1.18190 by International Journal of Reproductive BioMedicine in 2025
[2657]
ICSI for non-male infertility: from ineffectiveness to gender bias?
DOI:10.1016/j.rbmo.2024.104706 by Reproductive BioMedicine Online in 2025
[2568]
Non-Male Factor Only-ICSI Can Overcome Oocyte Factor in PCOS Patients
DOI:10.3390/jcm14010244 by Journal of Clinical Medicine in 2025
[2498]
Switching to intracytoplasmic sperm injection provides no benefit in couples of poor embryonic development in the previous in vitro fertilization cycle
DOI:10.1080/14647273.2024.2442451 by Human Fertility (Camb). in 2024
[2446]
Compared with conventional insemination, intracytoplasmic sperm injection provides no benefit in cases of nonmale factor infertility as evidenced by comparable euploidy rate
DOI:10.1016/j.fertnstert.2023.04.020 by Fertility and Sterility in 2024
[2382]
Intracytoplasmic sperm injection versus conventional in vitro fertilization in infertile couples with normal total sperm count and motility: does sperm morphology matter?
DOI:10.1093/humrep/deae252 by Human Reproduction in 2024
[2314]
Intracytoplasmic sperm injection compared with in vitro fertilisation in patients with non-male factor infertility with low oocyte retrieval: a single-centre, retrospective cohort study
DOI:10.1136/bmjopen-2023-080688 by BMJ Open. in 2024
[2305]
IVF Alerts
ICSI does not improve IVF outcomes for non-severe male factor infertility
